This book (Introduction, Review Literature) is attempt to focus on aspect of patient compliance. Adherence to chronic pharmacotherapy is poor. To better understand its relevance among vulnerable populations requires availability of a valid, reliable and practical measurement approach. Researchers have proposed various competing methods, including pill counts, self-report measures. Medication adherence is extent to which patients take medications as prescribed by their healthcare providers. Poor medication adherence diminishes the health benefits of pharmacotherapy. Elderly patients with coronary risk factors frequently require treatment with multiple medications, increased risk for nonadherence. This study is to test the efficacy of a comprehensive pharmacy care program to improve Medication adherence and its associated effects on BP and LDL-C. From this study, a pharmacy care program led to increases in adherence, medication persistence, and clinically meaningful reductions in BP and LDL level whereas discontinuation of the program was associated with decreased medication adherence and persistence. This book is not usual type book; we have tried to make it more reader friendly.