This volume presents the main findings of the research programme Technological Change and Regional Development in Europe, backed by the German Research Council. In doing so it examines the relationship between technological change and regional development by means of empirical surveys. In six years, a total of 50 research projects have been realised during three phases of two years. The surveys undertaken dealt with the manufacturing and service sector. In addition, numerous projects were carried out on the role that research institutions play in developing innovation processes in firms. The empirical surveys focused on Europe and covered regions in Germany, Great Britain, Netherlands, Spain, Slovenia, and Sweden.